The medication that is ‘best for treating bipolar disorder’
By Liz LockhartAn article published in the Pulse says that NICE guidelines currently do not recommend using any particular drug for acute mania. But in data the researchers say may change clinical guidelines, they found antipsychotics such as risperidone, haloperidol and planzapine were the most effective at treating acute mania, compared with placebo.
Published in The Lancet the systematic review looked at 68 randomised controlled trials of thirteen anti-mania drugs and compared their efficacy with placebo. The trials took place over a 20 year period and ended in 2010. It included male and female patients who were over the age of 18 and who had been diagnosed with bipolar disorder according to the standard diagnostic criteria.
The researched measured the mean change in scores on the Young Mania Rating Scale to gauge the efficiency of the different drugs. They also calculated the patient tolerability to the drugs by recording the number of patients who dropped out of the allocated treatment within the first three weeks. For each of these criteria the drugs were allotted a comparative score out of 50.
